Sunday, March 31, 2013

Drones over America: How unmanned fliers are already helping cops

It was getting dark, and the sheriff of Nelson County, N.D., was in a standoff with a family of suspected cattle rustlers. They were armed, and the last thing anybody wanted was a shoot out.

U.S. Customs and Border Protection, which monitors police radio chatter, offered to help. Their Predator was flying back to its roost at the Grand Forks Air Force base and could provide aerial support. Did the sheriff want the assist?

Yep.

"We were able to detect that one of the sons was sitting at the end of the driveway with a gun. We also knew that there were small children involved," Sheriff Kelly Janke told NBC News, remembering that tricky encounter in the early summer of 2011. "Someone would have gotten seriously injured if we had gone in on the farm that night." He decided to wait.

The next day, the drone gave them an edge again by helping them choose the safest moment to make a move. "We were able to surprise them ? took them into custody," Janke said. They also collected six stolen cows.

Rodney Brossart, the arrested farmer, sued the state, in part because of the cop's use of a drone. But a district judge ruled that the Predator's service was not untoward.

When advocates express concern about government drones threatening people's privacy, the Brossart case is one they bring up. It's one of the first instances of a flying robot doing a cop's dirty work, and this kind of intervention is likely to be more and more commonplace, as the FAA fulfills a congressional mandate to increase its granting of drone permits ? certificates of authorization, or COAs.

Cops and flying robots
At the moment, there are only 327 active COAs, all held by these organizations, and all for unarmed crafts, of course. A tiny sliver of these permits are in the hands of law enforcement agencies, and from them, we're seeing the first glimpses of drone use in policing and emergency response.

"The FAA has approved us to cover a 16-county area," Sheriff Bob Rost of Grand Forks County, N.D., said of their COA. "To look for missing children, to look for escaped criminals and in the case of emergencies." In the spring, they will use two mini-copter drones ? a trusty DraganFlyer X6 and an AeroVironment Qube ? to check on flooded farms.

The police department in Arlington, Texas, also recently got FAA clearance to fly their drones after two years of testing. The two battery-powered Leptron Avenger helicopter drones won't be used for high-speed chases or routine patrol, the department explains. In fact, the crafts will be driven in a truck to where they're needed, and when they're launched to scope out incidents, local air traffic control will be informed.

In Mesa County, Colo., the police department has used drones to find missing people, do an aerial landfill survey and help out firefighters at a burning church. For them, it's seen as a cost-cutting technology.

"It's the Wal-Mart version of what we'd normally get at Saks Fifth Avenue," said Benjamin Miller, who leads the drones program in Mesa County, comparing drones to manned helicopters that would otherwise give police officers help from the sky.

In Seattle, the police department received an FAA permit ? but had to give back its drones when the mayor banned their use, following protests in October 2012.

Protests and red tape
"Hasn't anyone heard of George Orwell's '1984'?" the Seattle Times quoted a protester as saying. "This is the militarization of our streets and now the air above us."

Protesters, not just in Seattle, seek more legal definition of what a drone can or can't do, and debate whether or not current laws sufficiently protect citizens from unauthorized surveillance and other abuses.

New York City mayor Michael Bloomberg thinks of police drones as an inevitability ? "We're going to have them," he recently said in a radio interview ? while those on the police (and drone) side say the fears are unfounded.

"This hysteria of [a drone] hovering outside your backyard taking a video of you smoking a joint, it's just that ? hysteria," said Al Frazier, an ex-cop from Los Angeles who is now an assistant professor of aeronautics at the University of North Dakota, and a deputy at the Grand Forks sheriff's office.

The reason the sky isn't lousy with drones already mostly has to do with red tape. The FAA's highly restricted drone application for government agencies is supposed to take about 60 days, though unofficially, we're told it's much longer. COAs are also very strict about where, when and by whom a drone is flown.

"I think there are many agencies who would like to use [drones] for public good, but they're stymied by the process," Frazier said.

That's likely to change ? and soon. Last February, Obama signed a mandate that encourages the FAA to let civil and commercial drones join the airspace by 2015. This will take new regulations from the FAA for safe commercial drone flight, and it may take some convincing of local anti-drone activists (who sometimes don't differentiate between drones great and small). It may even require the passing of a few new privacy laws.

Folks like Frazier and Miller don't see the permit process getting easier any time soon but eventually ? inevitably ? and for better or worse, your local police department will get its drone.

Nidhi Subbaraman writes about technology and science. Follow her on Twitter and Google+.

Related:

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Anticipating domestic boom, colleges rev up drone piloting programs

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Dolan: Catholic Church's Nature Means It Will be Out of Touch Sometimes (ABC News)

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Saturday, March 30, 2013

Former US soldier accused of fighting with al Qaeda group in Syria

via YouTube

Video of US Army veteran Eric Harroun filming militants celebrating a crashed helicopter was cited in the FBI affadavit. This clip has not been edited or verified by NBC News.

By Ian Johnston, Staff Writer, NBC News

A former U.S. soldier has been charged with fighting with an al Qaeda group in Syria after allegedly posting photographs of himself posing with military hardware on the internet, officials said in a statement.

Eric Harroun, 30, of Phoenix, Ariz., was accused of using a rocket-propelled grenade while fighting with the al-Nusrah Front, an alias of al Qaeda in Iraq, according to a statement issued on Thursday by the U.S. Attorney?s Office in the Eastern District of Virginia.

?Harroun, a U.S. citizen who served with the U. S. Army from 2000 to 2003, was charged by criminal complaint with conspiring to use a destructive device outside of the United States, which carries a maximum penalty of life in prison, if convicted,? the statement said.

?According to an affidavit filed in support of the criminal complaint, Harroun allegedly crossed into Syria in January 2013 and fought with members of the al-Nusrah Front against the Bashar al-Assad regime in Syria,? it added. ?The affidavit alleges that Harroun was trained to use an RPG by members of the terrorist organization and that he fired an RPG and posted online multiple photographs of himself carrying or posing with RPGs and other military weapons.?

?Harroun allegedly participated in attacks led by the al-Nusrah Front and was part of an RPG team, for which he carried anti-personnel and anti-armor rockets,? it said.

600 terrorist attacks
Al Qaeda in Iraq has been designated as a foreign terrorist organization since October 2004.

?The al-Nusrah Front is one of several aliases used by the 'al Qa?ida in Iraq' terrorist organization, and since November 2011 the group has claimed responsibility for nearly 600 terrorist attacks in Syria,? the statement said.

U.S. officials have called for Assad to step down in Syria and have offered non-lethal support to the rebels, but there is concern about militant groups like al Qaeda affiliates fighting alongside other rebel forces.

Israel fears al Qaeda elements will establish themselves close to the border and threaten to fire chemical weapons and long-range rockets captured from the Syrian army into Israel.

The statement said Harroun appeared in a federal court in Alexandria, Va., Thursday.

Harroun was arrested on Wednesday upon returning to the United States at an airport outside Washington, Reuters said. He has a hearing scheduled for Tuesday, the U.S. Attorney's office said.

He was medically discharged from the army after being injured in a car accident, according to an affidavit in support of a criminal complaint, Reuters reported.

The criminal charge of "conspiring to use a destructive device outside of the United States" carries a maximum penalty of life in prison.

Harroun appeared in two videos that indicated he was engaged in military action with rebel forces against the Syrian government, Reuters reported. In one video, he said: "Bashar al-Assad, your days are numbered. ... Where(ever) you go we will find you and kill you," according to the affidavit.

In March, the FBI conducted three voluntary interviews of Harroun at the U.S. Consulate in Istanbul, during which he stated that he wanted to fight with the Free Syrian Army against the Assad regime, the affidavit added.

Harroun allegedly told the FBI that during his fighting in Syria he shot about 10 people but did not know whether he killed any of them, the affidavit said, according to Reuters. He also said he hated al Qaeda and did not know any al Qaeda members, the affidavit said. On Wednesday in the United States, the FBI conducted another voluntary interview during which Harroun allegedly said that he knew the al-Nusrah Front had been designated a terrorist organization, according to the affidavit.

The U.S. Attorney's office said a lawyer would be appointed for Harroun, Reuters reported.

Reuters contributed to this report.

Related:

Syrian rebels ask US to shoot down Assad's warplanes with Patriot missiles

Arab nations set to declare the right to arm Syrian rebels

Syria chaos looms large over Obama's Israel trip

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Children with sleep apnea have higher risk of behavioral, adaptive and learning problems

Mar. 29, 2013 ? A new study found that obstructive sleep apnea, a common form of sleep-disordered breathing (SDB), is associated with increased rates of ADHD-like behavioral problems in children as well as other adaptive and learning problems.

"This study provides some helpful information for medical professionals consulting with parents about treatment options for children with SDB that, although it may remit, there are considerable behavioral risks associated with continued SDB," said Michelle Perfect, PhD, the study's lead author and assistant professor in the school psychology program in the department of disability and psychoeducational studies at the University of Arizona in Tucson. "School personnel should also consider the possibility that SDB contributes to difficulties with hyperactivity, learning and behavioral and emotional dysregulation in the classroom."

The five-year study, which appears in the April issue of the journal SLEEP, utilized data from a longitudinal cohort, the Tucson Children's Assessment of Sleep Apnea Study (TuCASA). The TuCASA study prospectively examined Hispanic and Caucasian children between 6 and 11 years of age to determine the prevalence and incidence of SDB and its effects on neurobehavioral functioning. The study involved 263 children who completed an overnight sleep study and a neurobehavioral battery of assessments that included parent and youth reported rating scales.

Results show that 23 children had incident sleep apnea that developed during the study period, and 21 children had persistent sleep apnea throughout the entire study. Another 41 children who initially had sleep apnea no longer had breathing problems during sleep at the five-year follow-up.

The odds of having behavioral problems were four to five times higher in children with incident sleep apnea and six times higher in children who had persistent sleep apnea. Compared to youth who never had SDB, children with sleep apnea were more likely to have parent-reported problems in the areas of hyperactivity, attention, disruptive behaviors, communication, social competency and self-care. Children with persistent sleep apnea also were seven times more likely to have parent-reported learning problems and three times more likely to have school grades of C or lower.

The authors report that this is the first sleep-related study to use a standardized questionnaire to assess adaptive functioning in typically developing youth with and without SDB.

"Even though SDB appears to decline into adolescence, taking a wait and see approach is risky and families and clinicians alike should identify potential treatments," said Perfect.

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Story Source:

The above story is reprinted from materials provided by American Academy of Sleep Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Michelle M. Perfect, Kristen Archbold, James L. Goodwin, Deborah Levine-Donnerstein, Stuart F. Quan. Risk of Behavioral and Adaptive Functioning Difficulties in Youth with Previous and Current Sleep Disordered Breathing. SLEEP, 2013; DOI: 10.5665/sleep.2536

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/ixobQhrv17k/130329161243.htm

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Duck Dynasty Season 4: Stalled Due to Contract Negotiations

Source: http://www.thehollywoodgossip.com/2013/03/duck-dynasty-season-4-stalled-due-to-contract-negotiations/

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Friday, March 29, 2013

Anna Chlumsky: Pregnant with First Child!

Source: http://www.thehollywoodgossip.com/2013/03/anna-chlumsky-pregnant-with-first-child/

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NOvA neutrino detector records first 3-D particle tracks

NOvA neutrino detector records first 3-D particle tracks [ Back to EurekAlert! ] Public release date: 28-Mar-2013
[ | E-mail | Share Share ]

Contact: Andre Salles
media@fnal.gov
630-840-6733
DOE/Fermi National Accelerator Laboratory

What will soon be the most powerful neutrino detector in the United States has recorded its first three-dimensional images of particles.

Using the first completed section of the NOvA neutrino detector, scientists have begun collecting data from cosmic raysparticles produced by a constant rain of atomic nuclei falling on the Earth's atmosphere from space.

"It's taken years of hard work and close collaboration among universities, national laboratories and private companies to get to this point," said Pier Oddone, director of the Department of Energy's Fermi National Accelerator Laboratory. Fermilab manages the project to construct the detector.

The active section of the detector, under construction in Ash River, Minn., is about 12 feet long, 15 feet wide and 20 feet tall. The full detector will measure more than 200 feet long, 50 feet wide and 50 feet tall.

Scientists' goal for the completed detector is to use it to discover properties of mysterious fundamental particles called neutrinos. Neutrinos are as abundant as cosmic rays in the atmosphere, but they have barely any mass and interact much more rarely with other matter. Many of the neutrinos around today are thought to have originated in the big bang.

"The more we know about neutrinos, the more we know about the early universe and about how our world works at its most basic level," said NOvA co-spokesperson Gary Feldman of Harvard University.

Later this year, Fermilab, outside of Chicago, will start sending a beam of neutrinos 500 miles through the earth to the NOvA detector near the Canadian border. When a neutrino interacts in the NOvA detector, the particles it produces leave trails of light in their wake. The detector records these streams of light, enabling physicists to identify the original neutrino and measure the amount of energy it had.

When cosmic rays pass through the NOvA detector, they leave straight tracks and deposit well-known amounts of energy. They are great for calibration, said Mat Muether, a Fermilab post-doctoral researcher who has been working on the detector.

"Everybody loves cosmic rays for this reason," Muether said. "They are simple and abundant and a perfect tool for tuning up a new detector."

The detector at its current size catches more than 1,000 cosmic rays per second. Naturally occurring neutrinos from cosmic rays, supernovae and the sun stream through the detector at the same time. But the flood of more visible cosmic-ray data makes it difficult to pick them out.

Once the upgraded Fermilab neutrino beam starts, the NOvA detector will take data every 1.3 seconds to synchronize with the Fermilab accelerator. Inside this short time window, the burst of neutrinos from Fermilab will be much easier to spot.

The NOvA detector will be operated by the University of Minnesota under a cooperative agreement with the U.S. Department of Energy's Office of Science.

The NOvA experiment is a collaboration of 180 scientists, technicians and students from 20 universities and laboratories in the U.S and another 14 institutions around the world. The scientists are funded by the U.S. Department of Energy, the National Science Foundation and funding agencies in the Czech Republic, Greece, India, Russia and the United Kingdom.

###

Fermilab is America's premier national laboratory for particle physics research. A U.S. Department of Energy Office of Science laboratory, Fermilab is located near Chicago, Illinois, and operated under contract by the Fermi Research Alliance, LLC. Visit Fermilab's website at http://www.fnal.gov and follow us on Twitter at @FermilabToday.

The DOE Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit science.energy.gov.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


NOvA neutrino detector records first 3-D particle tracks [ Back to EurekAlert! ] Public release date: 28-Mar-2013
[ | E-mail | Share Share ]

Contact: Andre Salles
media@fnal.gov
630-840-6733
DOE/Fermi National Accelerator Laboratory

What will soon be the most powerful neutrino detector in the United States has recorded its first three-dimensional images of particles.

Using the first completed section of the NOvA neutrino detector, scientists have begun collecting data from cosmic raysparticles produced by a constant rain of atomic nuclei falling on the Earth's atmosphere from space.

"It's taken years of hard work and close collaboration among universities, national laboratories and private companies to get to this point," said Pier Oddone, director of the Department of Energy's Fermi National Accelerator Laboratory. Fermilab manages the project to construct the detector.

The active section of the detector, under construction in Ash River, Minn., is about 12 feet long, 15 feet wide and 20 feet tall. The full detector will measure more than 200 feet long, 50 feet wide and 50 feet tall.

Scientists' goal for the completed detector is to use it to discover properties of mysterious fundamental particles called neutrinos. Neutrinos are as abundant as cosmic rays in the atmosphere, but they have barely any mass and interact much more rarely with other matter. Many of the neutrinos around today are thought to have originated in the big bang.

"The more we know about neutrinos, the more we know about the early universe and about how our world works at its most basic level," said NOvA co-spokesperson Gary Feldman of Harvard University.

Later this year, Fermilab, outside of Chicago, will start sending a beam of neutrinos 500 miles through the earth to the NOvA detector near the Canadian border. When a neutrino interacts in the NOvA detector, the particles it produces leave trails of light in their wake. The detector records these streams of light, enabling physicists to identify the original neutrino and measure the amount of energy it had.

When cosmic rays pass through the NOvA detector, they leave straight tracks and deposit well-known amounts of energy. They are great for calibration, said Mat Muether, a Fermilab post-doctoral researcher who has been working on the detector.

"Everybody loves cosmic rays for this reason," Muether said. "They are simple and abundant and a perfect tool for tuning up a new detector."

The detector at its current size catches more than 1,000 cosmic rays per second. Naturally occurring neutrinos from cosmic rays, supernovae and the sun stream through the detector at the same time. But the flood of more visible cosmic-ray data makes it difficult to pick them out.

Once the upgraded Fermilab neutrino beam starts, the NOvA detector will take data every 1.3 seconds to synchronize with the Fermilab accelerator. Inside this short time window, the burst of neutrinos from Fermilab will be much easier to spot.

The NOvA detector will be operated by the University of Minnesota under a cooperative agreement with the U.S. Department of Energy's Office of Science.

The NOvA experiment is a collaboration of 180 scientists, technicians and students from 20 universities and laboratories in the U.S and another 14 institutions around the world. The scientists are funded by the U.S. Department of Energy, the National Science Foundation and funding agencies in the Czech Republic, Greece, India, Russia and the United Kingdom.

###

Fermilab is America's premier national laboratory for particle physics research. A U.S. Department of Energy Office of Science laboratory, Fermilab is located near Chicago, Illinois, and operated under contract by the Fermi Research Alliance, LLC. Visit Fermilab's website at http://www.fnal.gov and follow us on Twitter at @FermilabToday.

The DOE Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit science.energy.gov.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/dnal-nnd032813.php

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Oculus founder: booze and Rift don't mix

Oculus Rift cofounder

You know that rule about not drinking and operating heavy machinery at the same time? You can widen that common-sense topic to include not getting tooled up before strapping the Oculus Rift to your face. In conversation with Joystiq, company founder Palmer Luckey has mentioned that the nausea-inducing effects of virtual reality can, unsurprisingly, become magnified if you combine it with the demon drink. Hey, it's something to bear in mind before you lose your lunch.

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Source: Joystiq

Source: http://www.engadget.com/2013/03/27/rift-and-booze-dont-mix/

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Thursday, March 28, 2013

Lawsuit over 'Bachelor' spoilers settled

Getty Images file

Sean Lowe of "The Bachelor."

By Eriq Gardner, The Hollywood Reporter

The 17th season of ABC's "The Bachelor" has ended, and producers have chosen ... settlement. At the beginning of the season, Sean Lowe was cast in the lead role, and "Reality" Steve Carbone was cast as the villain in a federal lawsuit that accused Carbone of attempting to induce contestants into breaching their confidentiality pledges.

PHOTOS: From Emma Stone to Jennifer Hudson, 12 reality stars turned actors

The lawsuit marked the second time that NZK Productions sued Carbone.

The first time came around the 16th season, and that too was settled. Then, weeks before the latest season premiered in January, Carbone posted spoilers on his website for the newest episodes of "The Bachelor," ?including the full names of the women eliminated from the competition. As a result, Carbone was charged with breaching the settlement agreement.

"Reality Steve" reacted with an anti-SLAPP motion, contending that the producers were using the court system improperly to interfere with his First Amendment rights.

His court papers also detailed the agreement that made the first lawsuit go away.

For five years from the time of the 2012 agreement, he was not to contact directly or indirectly any cast, crew or employees of "The Bachelor." ?But the agreement didn't explicitly bar him from being contacted by the cast, crew or employees. In such instances, he was to refrain from offering any financial incentives.

Carbone hasn't publicly revealed who has given him his scoops, and the latest lawsuit doesn't seem to have lasted long enough for producers to dig up such information in discovery.

STORY: "The Bachelor: The Women Tell All": 10 things you didn't see on TV

Of course, terms of the latest settlement have not been revealed. No word on what, if anything, Carbone gave to make the latest round of litigation go away. All the spoilermeister will say is that "the lawsuit has been amicably resolved."

From the archives of realitysteve.com, it appears that he reported that Lowe would be proposing to Catherine Giudici on November 26, 2012.

Last week, Carbone "confirmed" 13 of the 25 guys appearing on the coming season of "The Bachelorette" to premiere in May. The lawsuit is over, though. Until next season?

Related content:

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Source: http://theclicker.today.com/_news/2013/03/27/17486514-lawsuit-over-bachelor-spoilers-settled?lite

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Showpad Raises $2M Series A From Hummingbird Ventures To Hawk Its Sales Software For iPads To More Enterprises

showpadRiding the consumerisation of IT trend that's blowing the cobwebs off enterprise software, Belgian startup Showpad -- which makes iPad software for sales teams -- has raised a $2 million Series A funding round from early stage European VC firm, Hummingbird Ventures. Showpad said it plans to use the funding to grow its own sales and marketing team, and to "invest heavily" in platform development.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/BbM1wJ74eZI/

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Wednesday, March 27, 2013

ND gears up for legal dispute on new abortion laws

FILE - In this April 16, 2012 file photo North Dakota Gov. Jack Dalrymple speaks in Bismarck, N.D. Dalrymple signed legislation Tuesday, March 26, 2013 that that would make North Dakota the nation's most restrictive state on abortion rights, banning the procedure if a fetal heartbeat can be detected ? something that can happen as early as six weeks into a pregnancy. (AP Photo/Dale Wetzel, File)

FILE - In this April 16, 2012 file photo North Dakota Gov. Jack Dalrymple speaks in Bismarck, N.D. Dalrymple signed legislation Tuesday, March 26, 2013 that that would make North Dakota the nation's most restrictive state on abortion rights, banning the procedure if a fetal heartbeat can be detected ? something that can happen as early as six weeks into a pregnancy. (AP Photo/Dale Wetzel, File)

Map identifies states with time-based restrictions on abortions.

(AP) ? North Dakota's governor positioned the oil-rich state Tuesday as a primary battleground in the decades-old fight over abortion rights, signing into law the nation's toughest restriction on the procedure and urging lawmakers to set aside cash for an inevitable legal challenge.

Minutes after Republican Gov. Jack Dalrymple signed three anti-abortion measures ? one banning them when a heartbeat can be detected, which is as early as six weeks into a pregnancy ? unsolicited donations began pouring into the state's lone abortion clinic to help opponents prove the new laws are unconstitutional.

"Although the likelihood of this measure surviving a court challenge remains in question, this bill is nevertheless a legitimate attempt by a state legislature to discover the boundaries of Roe v. Wade," Dalrymple said in a statement, referring to the 1973 U.S. Supreme Court ruling that legalized abortion up to until a fetus is considered viable ? usually at 22 to 24 weeks.

In an interview later Tuesday, Dalrymple told The Associated Press that the courts opened the door for a challenge by picking a specific moment in the timeline of gestation. He also said he studied the fetal heartbeat bill and "educated myself on the history and legal aspects as best I could. My conclusion is not coming from any religious belief or personal experience."

Dalrymple seemed determined to open a legal debate on the legislation, acknowledging the constitutionality of the measure was an open question. He asked the Legislature to set aside money for a "litigation fund" that would allow the state's attorney general to defend the measure against lawsuits.

He said he didn't know how much the likely court fight would cost, but he said money wasn't the issue.

"The Legislature has decided to ask these questions on additional restrictions on abortions, and I think they have the legitimate right to ask those questions," he said.

He also signed into law measures that would makes North Dakota the first state to ban abortions based on genetic defects such as Down syndrome and require a doctor who performs abortions to be a physician with hospital-admitting privileges.

Lawmakers endorsed a fourth anti-abortion bill last week that would ban abortions after 20 weeks of pregnancy based on the disputed premise that fetuses feel pain at that point. The governor stopped short of saying he would sign it, but said: "I've already signed three bills. Draw your own conclusion."

The signed measures, which take effect Aug. 1, are fueled in part by an attempt to close the Red River Women's Clinic in Fargo ? the state's only abortion clinic.

Tammi Kromenaker, the clinic's director, called the legislation "extreme and unconstitutional" and said Dalrymple "awoke a sleeping giant" by approving it. The clinic, which performs about 3,000 abortions annually, was accepting cash donations and continued to take appointments Tuesday, she said.

"First and foremost, abortion is both legal and available in North Dakota," she said. "But anytime abortion laws are in the news, women are worried about access."

The Center for Reproductive Rights announced Tuesday that it has committed to challenging the fetal heartbeat bill on behalf of the clinic. The New York-based group already represented the clinic for free in a lawsuit over a 2011 law banning the widely accepted use of a medication that induces abortion. A judge has temporarily blocked enforcement of the law, and a trial is slated for April in Fargo.

Attorney General Wayne Stenehjem told the AP that lawyers from his office would defend any lawsuits that arise but an increase to the agency's budget would likely be necessary. He did not have a dollar amount.

The state has spent about $23,000 in legal costs to date defending the 2011 legislation, according to agency records obtained by the AP.

Julie Rikelman, litigation director for the Center for Reproductive Rights, said the group has provided three attorneys to argue that case. But in the recent round of legislation, the fetal heartbeat measure is the priority because it would effectively ban abortion in the state, she said.

"The impact is very, very clear," she said. "It would have an immediate and very large impact on the women in North Dakota."

Rikelman said the center also would support the clinic in other litigation, if need be and at no cost.

Kromenaker said other states have spent millions of dollars defending legislation, if the case reaches the nation's highest court. Rikelman said it's impossible to put a dollar amount on the impending legal fight in North Dakota.

"Litigation is so unpredictable," she said. "It could be very quick with a ruling in our favor."

North Dakota's law, since it would ban most abortions as early as six weeks into a pregnancy, goes further than a bill approved earlier this month in Arkansas that establishes a 12-week ban ? prohibiting them when a fetal heartbeat can be detected using an abdominal ultrasound. That ban is scheduled to take effect 90 days after the Arkansas Legislature adjourns.

A fetal heartbeat can generally be detected earlier in a pregnancy using a vaginal ultrasound, but Arkansas lawmakers balked at requiring women seeking abortions to have the more invasive imaging technique.

North Dakota's legislation doesn't specify how a fetal heartbeat would be detected.

Doctors performing an abortion after a heartbeat is detected could face a felony charge punishable by up to five years in prison and a $5,000 fine. Women having an abortion would not face charges.

The legislation to ban abortions based on genetic defects also would ban abortion based on gender selection. The Guttmacher Institute, which tracks abortion laws throughout the country, says Pennsylvania, Arizona and Oklahoma also have laws outlawing abortion based on gender selection.

The Republican-led North Dakota Legislature has endorsed a spate of anti-abortion Legislation this year. North Dakota lawmakers moved last week to outlaw abortion in the state by passing a resolution defining life as starting at conception, essentially banning abortion in the state. The measure is likely to come before voters in November 2014.

Dalrymple attended a groundbreaking ceremony Tuesday for a new diesel refinery in western North Dakota and made no public appearance to explain his signing of the abortion legislation.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-26-US-Abortion-North-Dakota/id-a7537bfccf054c4eaf515e2cb71c62f7

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Rove Sees Marriage Support in GOP 2016

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Social science struggles with effects of same-sex parenting on children (Washington Post)

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Tuesday, March 26, 2013

Atlanta food and drink events, March 25-31: a burger & beer ...

Source: http://clatl.com/omnivore/archives/2013/03/25/atlanta-food-and-drink-events-march-25-31-a-burger-and-beer-celebration-mustache-competition-and-more

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Nanowire solar cells raise efficiency limit

Mar. 24, 2013 ? Scientists from the Nano-Science Center at the Niels Bohr Institut, Denmark and the Ecole Polytechnique F?d?rale de Lausanne, Switzerland, have shown that a single nanowire can concentrate the sunlight up to 15 times of the normal sun light intensity. The results are surprising and the potential for developing a new type of highly efficient solar cells is great.

Due to some unique physical light absorption properties of nanowires, the limit of how much energy we can utilize from the sun's rays is higher than previous believed. These results demonstrate the great potential of development of nanowire-based solar cells, says PhD Peter Krogstrup on the surprising discovery that is described in the journal Nature Photonics.

The research groups have during recent years studied how to develop and improve the quality of the nanowire crystals, which is a cylindrical structure with a diameter of about 10,000 part of a human hair. The nanowires are predicted to have great potential in the development not only of solar cells, but also of future quantum computers and other electronic products.

It turns out that the nanowires naturally concentrate the sun's rays into a very small area in the crystal by up to a factor 15. Because the diameter of a nanowire crystal is smaller than the wavelength of the light coming from the sun it can cause resonances in the intensity of light in and around nanowires. Thus, the resonances can give a concentrated sunlight, where the energy is converted, which can be used to give a higher conversion effeciency of the sun's energy, says Peter Krogstrup, who with this discovery contributes to that the research in solar cell technology based on nanowires get a real boost.

New efficiency limit

The typical efficiency limit -- the so-called "Shockley-Queisser Limit" -- is a limit, which for many years has been a landmark for solar cells efficiency among researchers, but now it seems that it may be increased.

It's exciting as a researcher to move the theoretical limits, as we know. Although it does not sound like much, that the limit is moved by only a few percent, it will have a major impact on the development of solar cells, exploitation of nanowire solar rays and perhaps the extraction of energy at international level. However, it will take some years years before production of solar cells consisting of nanowires becomes a reality, says Peter Krogstrup who just completed his PhD at the Niels Bohr Institute, University of Copenhagen.

The research is conducted in collaboration with the Laboratory des Mat?riaux Semiconducteurs, Ecole Polytechnique F?d?rale de Lausanne, the Foundation and the company SunFlake A / S. Their scientific findings work support results published in the journal Science in January. Here, a group of researchers from Lund, showed that the sun's rays was sucked into the nanowires due to the high amount of power that their solar cell produced.

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The above story is reprinted from materials provided by University of Copenhagen - Niels Bohr Institute, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Peter Krogstrup, Henrik Ingerslev J?rgensen, Martin Heiss, Olivier Demichel, Jeppe V. Holm, Martin Aagesen, Jesper Nygard, Anna Fontcuberta i Morral. Single-nanowire solar cells beyond the Shockley?Queisser limit. Nature Photonics, 2013; DOI: 10.1038/nphoton.2013.32

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/GvlFiLzPecQ/130324152301.htm

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Sunday, March 24, 2013

US, Afghanistan OK detention center transfer

WASHINGTON (AP) ? The U.S. has reached an agreement with the Afghanistan government to transfer the Parwan Detention Facility to Afghan control, the Pentagon said Saturday, two weeks after negotiations broke down over whether the U.S. would have the power to block the release of some detainees.

According to a senior U.S. official, a key element to the agreement is that the Afghans can invoke a procedure that insures prisoners considered dangerous would not be released. The agreement also includes a provision that allows the two sides to work together to resolve any differences. The official lacked authorization to discuss the details of the agreement publicly and spoke on condition of anonymity.

Transfer of the Parwan detention center is critical to the ongoing effort to gradually shift control of the country's security to the Afghans as the U.S. and allies move toward the full withdrawal of combat troops by the end of 2014.

Afghans demanded control of the center, but U.S. officials have worried that the most threatening detainees would be freed once the U.S. transferred control. Defense Secretary Chuck Hagel spoke with Afghan President Hamid Karzai Saturday as officials finalized the agreement after days of intense negotiations.

The senior official said U.S. and Afghan officials who are familiar with the detainees would meet to assess the potential danger of their release to coalition forces. The official said that more senior level officials could be brought in if there are disagreements but that to date the two sides have been able to agree without bringing in those higher authorities.

Disagreements over the detention facility, which also included whether Afghans can be held without trial, had thrown a pall over the ongoing negotiations for a bilateral security agreement that would govern the presence of U.S. forces in Afghanistan after 2014.

Currently, there is an Afghan administrator of the Parwan prison, but the Americans have power to veto the release of detainees. The prisoners held under American authority do not have the right to a trial because the U.S. considers them part of an ongoing conflict.

Pentagon press secretary George Little said Hagel "welcomed President Karzai's commitment that the transfer will be carried out in a way that ensures the safety of the Afghan people and coalition forces by keeping dangerous individuals detained in a secure and humane manner in accordance with Afghan law."

Last weekend Hagel spoke with Karzai, and officials said the two men agreed to resolve the thorny issue within a week.

The top U.S. commander in Afghanistan, Marine Gen. Joseph Dunford, has also been working to resolve the matter ? one of several divisive issues that soured relations between the U.S., its allies and the Afghans in recent weeks.

The U.S. had been scheduled to hold a ceremony marking the transfer of control two weeks ago, during Hagel's first visit to Afghanistan as defense secretary. That ceremony was called off after negotiations broke down.

In addition to disputes over the Parwan facility, the U.S.-led coalition and Afghans have wrangled over several other difficult issues. Last month, Karza insisted that the coalition forces cease all airstrikes, after a NATO assault caused civilian casualties.

More recently, Karzai demanded that U.S. special operations forces leave Wardak province after allegations that U.S. commandos and their Afghan partners abused local citizens. Dunford has denied the charges.

Earlier this week, the two sides reached an agreement on the Warkak issue. Dunford agreed to remove a team of commandos from Wardak's Nirkh district and transition security of that area to the Afghans as soon as possible.

U.S. special operations forces would remain in other parts of the restive province, while the coalition continues to work to transition those areas also to the Afghans.

U.S. officials have made no final decision on how many troops might remain in Afghanistan after 2014, although they have said as many as many as 12,000 U.S. and coalition forces could remain.

There currently are 66,000 U.S. troops in Afghanistan, down from a 2010 peak of 100,000.

___

Lolita C. Baldor can be followed on Twitter: https://twitter.com/lbaldor

Source: http://news.yahoo.com/us-afghanistan-ok-detention-center-transfer-183406094--politics.html

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New US-EU talks threatened by agriculture spats

(AP) ? President Barack Obama used Washington's grandest stage ? the State of the Union speech ? to announce negotiations with Europe aimed at creating the world's largest free trade agreement. Just weeks later, there are signs that old agriculture disputes could be deal-killers.

European Union leaders don't want the negotiations to include discussions on their restrictions on genetically modified crops and other regulations that keep U.S. farm products out of Europe. But Obama says it's hard to imagine an agreement that doesn't address those issues. Powerful U.S. agricultural lobbies will do their best to make sure Congress rejects any pact that fails to address the restrictions.

"Any free trade agreement that doesn't cover agriculture is in trouble," said Cathleen Enright, executive vice president at the Biotechnology Industry Organization, which promotes biotechnology, including genetically modified products.

That would threaten the dream of a behemoth free trade deal between the world's two largest trading partners that together account for more than half of the world economy. It would lower tariffs and remove other trade barriers for most industries. Some analysts say the deal could boost each economy by more than a half-percentage point annually and significantly lower the cost of goods and services for consumers.

Agricultural issues have long bedeviled attempts to expand free trade across the Atlantic and have led each side to file complaints against the other before the World Trade Organization, an arbitrator in trade disputes. While the U.S. protests EU restrictions, Europeans want the U.S. to reduce agricultural subsidies.

Genetically modified organisms, or GMOs, have been a core part of the dispute. Agricultural scientists change the genetic makeup of agricultural products to improve their quality and boost production. In Europe, there is widespread public opposition to GMOs. The EU argues that the risks of altering the genetic pool are unknown. It has strict rules and imposes a heavy burden of proof before such crops can be grown or imported in the EU.

U.S. companies say that genetically modified products have been proved safe by scientific studies and are being excluded based on irrational fears. They accuse Europe of trying to help their own farmers by keeping out American products.

While they have little expectation that the EU would end the restrictions, they say it would be a victory if it clarified what it describes as opaque rules and also set timelines for considering products. Regulators now take what they call a precautionary approach, declining approval of products until they can be more certain of their safety.

But any move to water down the regulations could provoke a backlash in Europe.

"My reading of the mood in Europe around genetically modified crops is that it's extremely negative," said Paul DeGrauwe, a professor of economics at the London School of Economics. "It's going to be very difficult."

Indeed, the top EU trade negotiator, Commissioner Karel De Gucht, seemed to rule out a compromise in remarks this month: "A future deal will not change the existing legislation. Let me repeat: no change."

The U.S. and the EU have similarly intractable disagreements on what the two sides call sanitary issues in meats. U.S. poultry products are restricted in the EU because U.S. companies use chlorine to sanitize the meat. Pork is also restricted because U.S. farmers use a feed additive that makes pigs leaner. The two sides partially resolved disputes over U.S. beef after an agreement that U.S. farmers would restrict hormones in cows intended for the European market.

Some European officials say the agricultural differences should be discussed after a major trade deal is completed. This month, French President Francois Hollande called for excluding sensitive issues, including the sanitary standards, from the talks. In the past, France has been among the most adamant of the European countries about protecting agricultural interests.

Obama, in a talk with his export council this month, suggested this could be a deal-breaker.

"There are certain countries whose agricultural sector is very strong, who tended to block at critical junctures the kinds of broad-based trade agreements that would make it a good deal for us," he said. "If one of the areas where we've got the greatest comparative advantage is cordoned off from an overall trade deal, it's very hard to get something going."

Powerful U.S. agricultural groups could probably block a trade deal from winning approval in Congress. In interviews, representatives of many of these groups said they would oppose a deal that didn't address the regulatory differences.

Robert Thompson, an academic at Johns Hopkins University and a former economist for the Agriculture Department, said that the agricultural issues could easily upend the talks.

"I'm not expecting an agreement to emerge any time soon," he said. "I'm thinking years."

Of course, the rhetoric at the beginning of talks might not preclude compromise in the end. In his talk with the export council, Obama expressed optimism. He noted that austerity measures in response to the debt crisis in the EU have caused European countries to look to a free trade deal as a rare opportunity to boost the economy and improve competitiveness.

"I think they are hungrier for a deal than they have been in the past," he said.

___

Melvin reported from Brussels.

___

Follow Desmond Butler on Twitter at http://twitter.com/desmondbutler

Follow Don Melvin on Twitter at http://twitter.com/Don_Melvin

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-23-US-EU-Trade/id-6f0309c29ae04a56a2f9f0c2d7def4ee

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Impact?beat NY,?stay perfect? |? Revs?tie SKC

Associated Press Sports

updated 7:53 p.m. ET March 23, 2013

MONTREAL (AP) - Marco Di Vaio scored in the 14th minute and the Montreal Impact beat the New York Red Bulls 1-0 on Saturday to improve to 4-0.

New York (0-2-2) finished the match short a man after defender Brandon Barklage was sent off for taking down Patrice Bernier at the edge of the penalty area in the 74th minute.

The Red Bulls had a slight edge in ball possession, but the Impact dominated the scoring chances and wasted a handful of opportunities to pad the lead.

"We're in a good way now in terms of results," Impact captain Davy Arnaud said. "The performance was also better than last week against Toronto (a 2-1 win in their home opener). ... They had some fresh legs coming in and were pushing guys forward, but we stayed solid and ended the game well."

A crowd of 26,259 saw Di Vaio whiff on a perfect setup from Andres Romero, have a shot from the left side blocked by Luis Robles and tip another ball just wide in the second half alone.

The Impact scored first for a fourth straight game in the 14th when goalkeeper Troy Perkins sent a long ball up the middle that was headed down to Bernier. The playmaker slipped a pass through the New York defense to Di Vaio, who beat Robles to the left side for his second goal of the season.

"This really stung," Robles said. "I felt like we did a lot of things good, but sometimes that's not good enough. "We all know it's a long season, but we don't want to be looking 10 or 15 games in and thinking `OK, there's more of the season left.' It doesn't work that way.

"We wanted to do bring the game to Montreal. We were doing that, but also give credit them credit. Montreal is very organized and compact. There's a reason they're 4-0."

The Red Bulls new signing from Paris St. Germain, Peguy Luyindula, played his first game at forward and had his side's best chance of the first half. Heath Pearce's attempt off Juninho's free kick was deflected by Perkins to the top of the box, where Luyindula chipped it over the bar in the 38th minute. And Luyindula was in front again in the second, but only got a touch on a feed from the right side and was stopped by Perkins.

Thierry Henry wasn't available for New York because of a knee injury.

The Impact played their first two home games in Olympic Stadium and will move outdoors to Saputo Stadium for an April 16 match with Columbus.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Hair Today Gone Tomorrow ? Can Menopausal Hair Loss Be ...

Related eBooks

Studies show that up to 40% of women experience hair loss or hair thinning during menopause or in the four to five year period before menopause (perimenopause). Although there are no overnight solutions to menopausal hair loss, there are a number of steps you can take to remedy the situation.

Source:Hair Today Gone Tomorrow ? Can Menopausal Hair Loss Be Reversed?

Related Reading:

The Cleveland Clinic Guide to Menopause (Cleveland Clinic Guides)The Cleveland Clinic Guide to Menopause (Cleveland Clinic Guides)From the nation?s top-ranked clinic for gynecology and endocrinology, the most important health information and advice on what to do before and during menopause

Regain Control and Enjoy A Vibrant, Healthy Midlife!

If you are one of the millions of women who want answers about menopause, help has arrived: Discover leading-edge menopause treatments that offer effective relief from symptoms, and gain optimism and peace of mind about your health!

In The Cleveland Clinic Guide to Menopause, Dr. Holly Thacker, a trailblazer in women?s health, cuts through the myths and misinformation and provides solid information to help you handle menopause more effectively. She also offers advice that helps you improve your vitality, longevity, and quality of life. Inside you?ll find guidance to help you:

  • Control menopause symptoms through safe, effective treatments that balance short-term results with your long-term health.
  • Understand the myths and facts about hormone therapy and sort through the inaccurate, misleading and conflicting information that?s so prevalent today.
  • Sleep better, boost your energy, and recharge your sex life?so you can regain short term results you want!
  • Get the facts about vitamins, supplements, and antidepressants.
  • Protect your long-term health by strengthening your bones, helping your heart, and taking smart steps to help prevent cancer and other diseases.

Cleveland Clinic is ranked consistently among the top hospitals in America by U.S. News & World Report. Its team of Women?s Health professionals offers coordinated, supportive care for the problems that affect women's lives, from breast cancer and infertility, to incontinence, pelvic floor disorders, and more.

No More HRT: Menopause - Treat the CauseNo More HRT: Menopause - Treat the CauseContrary to popular opinion menopause is not a disease but a normal process in woman?s life - a time when the mental, emotional, physical and spiritual-self need nurturing. Hot flashes, night sweats, memory problems, fatigue, weight gain, loss of libido or headaches are blamed on the decreased production of hormones when the true cause is imbalanced adrenal glands, liver, thyroid and digestive function.

Along with equality, women have gained too much daily stress with increased work loads, lack of physical and spiritual exercise, insufficient rest, poor diet, environmental toxins including the exposure to toxic estrogens in the environment, all contributors to a difficult menopause.

No More HRT: Menopause Treat the Cause provides you with the key to a symptom-free menopause. Dr. Karen Jensen and Lorna Vanderhaeghe recommend treating the cause of women?s health problems by supporting the body with a healthy diet and lifestyle at an early age, to prevent PMS, fibroids, endometriosis, infertility, heavy periods, hot flashes, night sweats, breast and ovarian cysts, menopause and more. With love, they have put together a simple program to ensure vibrant health.

Life is a continuous adventure that requires mental, emotional, physical and spiritual stamina during the hormonal transitional years and always. This book offers many tips and insights that can help women accomplish this.

From this book you will learn:

  • Why weak adrenals and low thyroid worsen menopausal symptoms
  • New ways to improve energy
  • How to enhance your flagging libido
  • Calming remedies for peaceful sleep
  • How to protect your bones, heart and memory
  • Treatment strategies for uterine fibroids, ovarian cysts, heavy menstruation and more
  • Discover nutrients to slow aging
  • Why hormone imbalance makes you fat
  • How to improve thyroid function
. . . and much, much more.
The Truth About Hormone Replacement Therapy: How to Break Free from the Medical Myths of MenopauseThe Truth About Hormone Replacement Therapy: How to Break Free from the Medical Myths of MenopauseJust Say No to America's Number-One Drug
Menopause is not a disease. So why are millions of American women taking a drug for this natural body process?
The widespread popularity of hormone replacement therapy (HRT) is a triumph of marketing and advertising over science. Although HRT and estrogen replacement therapy (ERT) can help some women with certain menopause-related problems, the benefits have been oversold to women and their health care providers. There is no scientifically valid evidence that estrogen prevents heart disease, colon cancer, or Alzheimer's. Nor is there any evidence that it keeps you looking younger, preserves your sex drive, or enhances your memory.
However, HRT does carry the risk of serious side effects, including certain cancers. Should you be taking such risky drugs to help you get through menopause? The Truth About Hormone Replacement Therapy, written by the National Women's Health Network, will help you decide. Inside, you'll discover:
?The risks of hormone replacement therapy
?How to talk to your doctor about HRT
?The truth about hormone therapy and osteoporosis
?Natural alternatives to relieve perimenopausal and menopausal symptoms
?And much more
This sensible health guide gives you the tools you need to make an informed decision that's best for you and your body.
"A balanced review of the hazards and potential benefits of hormone therapy after menopause."
?Graham A. Colditz, M.D., professor of medicine, Harvard Medical School
The Natural Menopause Solution: Expert Advice for Melting Stubborn Midlife Pounds, Reducing Hot Flashes, and Getting Relief from Menopause SymptomsThe Natural Menopause Solution: Expert Advice for Melting Stubborn Midlife Pounds, Reducing Hot Flashes, and Getting Relief from Menopause Symptoms

For far too long, doctors thought hormone replacement therapy was the answer to menopausal symptoms from hot flashes to sleepless nights to stubborn belly fat. But while it does help, HRT can be risky?and may raise women?s chances for breast cancer, heart attack, and stroke. Luckily, there?s a growing stack of research that natural remedies can be just as effective.

In The Natural Menopause Solution, the editors of Prevention and integrative medicine specialist Melinda Ring, MD, distill that research into the easy-to-follow 30-Day Slim-Down, Cool-Down Diet, which can help women lose 21 percent more body weight. Plus it?s proven to help reduce the number and intensity of hot flashes by 50 percent. In addition to this easy eating and exercise program, there are hundreds of drug-free solutions for sleep problems, memory lapses, mood swings, lack of energy, low libido, and more?and strategies to protect against heart disease, diabetes, stroke, osteoporosis, and cancer.

Source: http://www.jackiesbazaar.com/womensinterests/menopause-hrt/hair-today-gone-tomorrow-can-menopausal-hair-loss-be-reversed

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Saturday, March 23, 2013

Scientists reveal quirky feature of Lyme disease bacteria

Friday, March 22, 2013

Scientists have confirmed that the pathogen that causes Lyme Disease?unlike any other known organism?can exist without iron, a metal that all other life needs to make proteins and enzymes. Instead of iron, the bacteria substitute manganese to make an essential enzyme, thus eluding immune system defenses that protect the body by starving pathogens of iron.

To cause disease, Borrelia burgdorferi requires unusually high levels of manganese, scientists at Johns Hopkins University (JHU), Woods Hole Oceanographic Institution (WHOI), and the University of Texas reported. Their study, published March 22, 2013, in the Journal of Biological Chemistry, may explain some mysteries about why Lyme Disease is slow-growing and hard to detect and treat. The findings also open the door to search for new therapies to thwart the bacterium by targeting manganese.

"When we become infected with pathogens, from tuberculosis to yeast infections, the body has natural immunological responses," said Valeria Culotta, a molecular biologist at the JHU Bloomberg School of Public Health. The liver produces hepcidin, a hormone that inhibits iron from being absorbed in the gut and also prevents it from getting into the bloodstream. "We become anemic, which is one reason we feel terrible, but it effectively starves pathogens of iron they need to grow and survive," she said.

Borrelia, with no need for iron,has evolved to evade that defense mechanism. In 2000, groundbreaking research on Borrelia's genome by James Posey and Frank Gherardini at the University of Georgia showed that the bacterium has no genes that code to make iron-containing proteins and typically do not accumulate any detectable iron.

Culotta's lab at JHU investigates what she called "metal-trafficking" in organisms??the biochemical mechanisms that cells and pathogens such as Borrelia use to acquire and manipulate metal ions for their biological purposes.

"If Borrelia doesn't use iron, what does it use?" Culotta asked.

To find out, Culotta's lab joined forces with Mak Saito, a marine chemist at WHOI, who had developed techniques to explore how marine life uses metals. Saito was particularly intrigued because of the high incidence of Lyme Disease on Cape Cod, where WHOI is located, and because he specializes in metalloproteins, which contain iron, zinc, cobalt, and other elements often seen in vitamin supplements. The metals serve as linchpins, binding to enzymes. They help determine the enzymes' distinctive three-dimensional shapes and the specific chemical reactions they catalyze.

It's difficult to identify what metals are within proteins because typical analyses break apart proteins, often separating metal from protein. Saito used a liquid chromatography mass spectrometer to distinguish and measure separate individual Borrelia proteins according to their chemical properties and infinitesimal differences in their masses. Then he used an inductively coupled plasma mass spectrometer to detect and measure metals down to parts per trillion. Together, the combined analyses not only measured the amounts of metals and proteins, they showed that the metals are components of the proteins.

"The tools he has are fantastic," Culotta said. "Not too many people have this set of tools to detect metalloproteins."

The experiments revealed that instead of iron, Borrelia uses that element's next-door neighbor on the periodic chart, manganese, in certain Borrelia enzymes. These include an amino peptidase and an important antioxidant enzyme called superoxide dismutase.

Superoxide dismutase protects the pathogens against a second defense mechanism that the body throws against them. The body bombards pathogens with superoxide radicals, highly reactive molecules that cause damage within the pathogens. Superoxide dismutase is like an antioxidant that neutralizes the superoxides so that the pathogens can continue to grow.

The discoveries open new possibilities for therapies, Culotta said. "The only therapy for Lyme Disease right now are antibiotics like penicillin, which are effective if the disease is detected early enough. It works by attacking the bacteria's cell walls. But certain forms of Borrelia, such as the L-form, can be resistant because they are deficient in cell walls."

"So we'd like to find targets inside pathogenic cell that could thwart their growth," she continued. "The best targets are enzymes that the pathogens have, but people do not, so they would kill the pathogens but not harm people." Borrelia's distinctive manganese-containing enzymes such as superoxide dismutase may have such attributes.

In search of new avenues of attack, the groups are planning to expand their collaborative efforts by mapping out all the metal-binding proteins that Borellia uses and investigating biochemical mechanisms that the bacteria use to acquire manganese and directs it into essential enzymes. Knowing details of how that happens offers ways to disrupt the process and deter Lyme Disease.

###

Woods Hole Oceanographic Institution: http://www.whoi.edu

Thanks to Woods Hole Oceanographic Institution for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127404/Scientists_reveal_quirky_feature_of_Lyme_disease_bacteria

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